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Drug Release Study of Nalidixic acid from the Chitosan- Carrageenan Ionic Matrix | ||
| basrah journal of science | ||
| Article 1, Volume 25, Issue 1, 2007, Pages 104-118 PDF (0 K) | ||
| Authors | ||
| Luma J.AL-Amber; Zeki N. AL-Sokanee; Kadhmia W. AL- Chezzy; Tahseen A.Saki | ||
| Abstract | ||
| A new ionic matrix hydrogel based on chitosan and k-carrageenan was prepared by the ioncally crosslinked. Carrageenan is a sulphated polysaccharide (negatively charged), when mixed with chitosan (positively charged) the ionicaly matrix is formed. The matrix is characterized by the FT.IR spectroscopy and solubility properties. The aim of nalidixic acid loaded is to retarded the fast excretion of drug from the urinary tract by imbedded into the matrix and decreasing of the dose quantity of drug and removal the side effect of the crosslinking agents. A good release obtain by examination the matrix loaded by using different pH, the release of drug at pH=7.4 consumed 60 min on best quantity of drug. | ||
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