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Polymorphism of ABO and MNS Blood Group Systems in Beta-Thalassemia | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 3, Issue 2, 2010, Pages 65-69 | ||
| Authors | ||
| Zainab Sabah Hassab; Nasr F. Abdullah; Yakub Abd-Alwahed Saleh | ||
| Abstract | ||
| The ABO and MNS were typed in a sample consisted of 381 individuals, a one hundred of them present the control whereas the remaining 281 individuals were affected by β-thalassemia. The latter sample was divided into three types; 158 person affected with major thalassemia, 67 persons affected with intermediate thalassemia and 56 persons affected with minor thalassemia (carriers). The present study aims to explore for any relation in frequency of the two blood group patterns and the ability to be affected by β-thalassemia and each of its three clinical sub-types by comparison with the control sample. The various comparisons lead to: There is significant difference (P<0.05) in frequency of ABO group for β-thalassemia patients, especially major-thalassemia (P<0.01). The reasen for this difference is an increase in group A in the patients and a decrease in group O. There are highly significant differences system in MN (P<0.001) for β-thalassemia and other subtypes, except the minor. The M+N+ phenotype was highly expressed, while the M+N- phenotype was depressed. There is also highly significant difference for Ss in major thalassemia only. The S+s+ phenotype was increased, while the S-S+ was decreased. | ||
| Keywords | ||
| ABO; MNS | ||
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