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Effect of Pomegranate extract on P53 expression in Cancer Cell line (Hep-2) | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 4, Issue 1, 2011, Pages 29-34 | ||
| Authors | ||
| Zaynab S. Abdul-Gany; Maeda H. Mohammad | ||
| Abstract | ||
| Background: Pomegranate (Punica granatum) fruits are widely consumed as juice. The potent antioxidant and antiatherosclerotic activities of pomegranate are attributed to its polyphenols. Aim: Pomegranate extract were evaluated for in vitro cytotoxic and its effect on the level of p53 in Hep2 (Human larynx epidermal carcinoma). Methods: Aqueous extraction of pomegranate was prepared and in vitro cytotoxicity and amount of p53 was evaluated on cancer cell line Hep2 (Human larynx epidermal carcinoma). Results: The study showed that the pomegranate extract has greatest antiproliferative activity by inhibition proliferation from 13% to 73.9%, at 10 μg/ml and 24 hr period of exposure. Also, the study showed significant decrease of p53 in treated group in comparison to control. Conclusions: According to the in vitro antiproliferative activity, inhibition of p53 expression pomegramate extracts may be possess a potent anticancer activity. | ||
| Keywords | ||
| pomegranate extract; cytotoxicity; cancer cell lines | ||
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