S. Salmman, A., Isra, , Y. Yaseen, N., A. Ahmed, A., H. Mohammad, M., R. Taha, Z., K. Shaker, H., A. Hassan, A. (2011). The Effect of Flavonoids on Cancer and Normal Cell Lines invitro. , 4(1), 94-100.
a S. Salmman; Isra; Nahi Y. Yaseen; Aesar A. Ahmed; Maeda H. Mohammad; Zahraa R. Taha; Hiba K. Shaker; Ayman A. Hassan. "The Effect of Flavonoids on Cancer and Normal Cell Lines invitro". , 4, 1, 2011, 94-100.
S. Salmman, A., Isra, , Y. Yaseen, N., A. Ahmed, A., H. Mohammad, M., R. Taha, Z., K. Shaker, H., A. Hassan, A. (2011). 'The Effect of Flavonoids on Cancer and Normal Cell Lines invitro', , 4(1), pp. 94-100.
S. Salmman, A., Isra, , Y. Yaseen, N., A. Ahmed, A., H. Mohammad, M., R. Taha, Z., K. Shaker, H., A. Hassan, A. The Effect of Flavonoids on Cancer and Normal Cell Lines invitro. , 2011; 4(1): 94-100.

The Effect of Flavonoids on Cancer and Normal Cell Lines invitro

Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 4, Issue 1, 2011, Pages 94-100
Authors
a S. Salmman; ; Nahi Y. Yaseen; Aesar A. Ahmed; Maeda H. Mohammad; Zahraa R. Taha; Hiba K. Shaker; Ayman A. Hassan
Abstract
This study was aimed to know the inhibitory effect of the flavonoid extract of Silybum marianum seeds on two of
the cancer cell lines , human brain cancinoma(AMGM), human cervix uteri epitheloid carcinoma (Hela ) and one
normal cell line , Mouse embryonic fibroblast cell line (MEF). The concentration was (1000,500,250,125,62.5) μg/ml
respectively with two exposure time (24 & 48) hours for the cancer cell lines and one exposure time (48) hr. for the
normal one .
The results showed that flavonoids extract has obvious inhibitory effect on (human brain carcinoma & Hela) with
(P<0.05) significantly in high concentration (1000) μg/ml the cellular density (obsorption) of human brain carcinoma
was (0.052) with inhibitory ratio (39%) compared with control , At 48 hours exposure the density was (0.051) with
inhibitory ratio (94%) compared with control , whereas the density in Hela was (0.059, 0.06) with inhibitory ratio85.7%
and 86% respectively at 24 and 48 hr. exposure .
While the normal cell line showed no signification effect (P<0.05) for all brevious concentration except the high one
(1000) μg/ml , whereas the density of MEF was (0.23), with inhibitory effect (34%) .
The result of this study has indicated ahighest inhibitory activity of the cancer cell lines for both AMGM & Hela .
Keywords
Silybum marianum; AMGM
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