Polymorphism of Lewis and Kell  Blood Group  Systems  in Beta-Thalassemia

Abd-Alwahed  Saleh, Yakub; F. Abdullah, Nasr; Sabah Hassab, Zainab

	Polymorphism of Lewis and Kell Blood Group Systems in Beta-Thalassemia
Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 3, Issue 1, 2010, Pages 99-104
Authors
Yakub Abd-Alwahed Saleh; Nasr F. Abdullah; Zainab Sabah Hassab
Abstract
Pattern of the Lewis and Kell blood groups were determined in a sample consisted of 381 individuals. A one hundred of this sample represents the control, whilst the remaining individuals (281) were affected by β-thalassemia. The latter, was divided into 158 individuals affected with major thala.; 67 individuals affected with intermediate thala. and 56 individuals affected with minor thala. (carriers). The various comparisons between the studied blood sample revealed the existence of significant differences between the Lewis blood group for β-thala.; also between each of its three types(major, intermediate and minor) as compared with the control sample. This difference was attributed to decrease in resistant phenotype Le(a-b+) and relative increase in Le (a-b-) phenotype. The Kell blood group did not differ significantly in the types of this disease. It appears, the importance of Lewis blood group as another source for detecting the risk of inheritance for β-thala. and other common genetic diseases, because its phenotypes reflect the variation between various samples. It can be used in concordance with other laboratory tests in genetic counseling. It was recommended to do more studies about the other secondary blood groups in order to known the frequency of its patterns between the normal and disease samples.
Keywords
Thalassemia; Lewis; Kell blood systems; polymorphism

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