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Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles | ||
| Journal of Education and Science | ||
| Article 6, Volume 21, Issue 3, 2008, Pages 54-61 PDF (0 K) | ||
| DOI: 10.33899/edusj.2008.56050 | ||
| Author | ||
| Yaser S. Al-Jawharji | ||
| Abstract | ||
| ABSTRACT In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl glycine with thionyl chloride followed by treatment the product (3,4) with ammonium hydroxide to give N-aroyl glycine amide (5,6). Treatment of the amide with 1-bromocyclohexanone gave N-methylene-2-hexahydrobenzoxazole) aryl amide (7,8), cyclization of this gave product (9,10), whereas the compounds (13,14) was synthesized from o-aminophenol and the acid chlorides to give N-methylene (2-benzoxazole) aryl amide (11,12) which cyclized with phosphorous oxychloride to give the products (13,14). The structure of all synthesized compounds were confirmed by physical and spectral data. | ||
| Keywords | ||
| synthesis; Substituted Benzoxazole; imidazole | ||
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