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Study the anticancer activity of plant phenolic compounds | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 4, Issue 2, 2011, Pages 66-71 | ||
| Authors | ||
| Ali I. Obied; Raad M. Hanaon; Nahi Y. Yaseen; Wathq S. Abdul alhussain; Haider R. Maleh | ||
| Abstract | ||
| This study was carried out to extract the phenolic compounds from tea leaves and pomegranate peel. It appeared that tea leaves contain 7 phenolic compounds: epigallocatechin-3-O-gallate, epigallocatechin, catechin, quercetin, myricitin, rutin, and gallic acid. Their concentrations were 8.9, 6.6, 2.4, 1.8, 1.4, 1.2, and 0.9 mg/g respectively. The total amount of phenolic compounds in tea leaves was 23.2 mg/g. The pomegranate peel contained 3 phenolic compounds: tannic acid, ellagic acid and gallic acid with a concentration of 2.0, 5.3, and 407 respectively. The total amount of phenolic compounds in pomegranate peel was 12.00 mg/g. Both tea leaves and pomegranate peel extracts inhibit the proliferation of two cancer cell lines, AMN3 and Hela with a concentration of 125, 250, and 500 ug/ml, and there was a positive concentration – effect relationship. The results were discussed according to the previously known biological effects of phenolic compounds. | ||
| Keywords | ||
| epigallocatechin; gallate | ||
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