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Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction | ||
| Journal of Education and Science | ||
| Article 3, Volume 22, Issue 1, 2009, Pages 19-31 PDF (0 K) | ||
| DOI: 10.33899/edusj.2009.57438 | ||
| Authors | ||
| Nabeel Sabeh Othman* ; Shilan Ali Omer | ||
| Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| ABSTRACT A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow azo dye with maximum absorption at 387 nm. Beer’s law is obeyed in the concentration range of 20-280g of bromhexine-HCl in a final volume of 25 ml (0.8- 11.2 ppm) with a molar absorptivity of 1.031104 L.mol-1.cm-1, a relative error of -0.36 to +0.72 % and a relative standard deviation of 1.07 to 1.72 %, depending on the concentration level of bromhexine-HCl. The method has been successfully applied for the assay of bromhexine-HCl in various pharmaceutical preparations. | ||
| Keywords | ||
| Spectrophotometric determination; Bromhexine hydrochloride; Azo-Dye Formation Reaction | ||
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