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Invitro evaluation controlled release study for Metforminhydrochloride polymeric hydrogel matrixes | ||
| basrah journal of science | ||
| Article 1, Volume 23, Issue 1, 2005, Pages 106-117 PDF (0 K) | ||
| Authors | ||
| ; E.M. Al-Zubaidi; | ||
| Abstract | ||
| The hydroxyethlcellulose hyrogels were prepared by its chemical crosslinking using glyceraldhyde , and tetramethylolurea resin in the presence of sulfuric acid . Several tablets were prepared as polymetic matrix and polymetric reservoir systems from hydroxyethylcellulose hydrogels , loaded with Metformin hydrochloride in several ratios (25%,34%,50% wt/wt) . The two polymeric matrix system were prepared by compression molding and dip coating process respectively . The release rate of Metformin hydrochloride from polymeric matrix device was studied by using U.V. technique at constant tmperatur (37◦C) . The effect of pH on the release rate of Metformin hydrochloride in ( PBS; pH=7.4) , SGF , and SIF was studied . The swelling behavior of some prepared sample was also studied , the result showed greater increase in swelling ratio at lower pH valus . | ||
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