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Synthesis of some substituted pyrimidines via cycloaddition reaction of amidines and chalcones | ||
| Journal of Education and Science | ||
| Article 5, Volume 22, Issue 2, 2009, Pages 38-46 PDF (0 K) | ||
| DOI: 10.33899/edusj.2009.57680 | ||
| Authors | ||
| H. M. Al-Ajely; G. T. Sedeek; M. S. Al-Ajely | ||
| Abstract | ||
| ABSTRACT Substituted amidines (1,2) where prepared from the condensation of benzyl, furfuryl alcohols and ethyl sulphate with thiourea. Chalcone compounds (3,5a and 5b) where also prepared from condensation of 4-nitrobenzaldehyde to give compound (3) while acetophenone, 4-hydroxy benzaldehyde and 1,3-dibromopropane gave the diformyl intermediate (4) then it was underwent further reaction with either acetophenone or 4-methyl acetophenone to afford compounds (5a,5b) respectively. Condensation of the above amidines with the resulted chalcones or dichalcones afforded the substituted pyrimidines (6-11). Their structures confirmation were studied by IR and were discussed. | ||
| Keywords | ||
| substituted pyrimidines; cycloaddition reaction; amidines; Chalcones | ||
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