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• An Interaction Study between Acetylsalicylic Acid (Aspirin) and Captopril at Different Doses in Rats | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 2, Issue 4, 2009, Pages 387-396 PDF (0 K) | ||
| Authors | ||
| Dr. Najah R. Hadi; Duraid A. Abbas; Saadia S. Mehdy | ||
| Abstract | ||
| the present studies were used forty nine rats to determine chronic toxicity effect which were divided into 4 groups, the control group (7 rats) received distilled water, the other three treatment groups each group (14) rats were divided into two subgroups T1&T2 according to the following oral daily dosing regiment ( aspirin subgroup 2 and 4 mg/kg , captopril, 6 and 12 mg/kg and aspirin + captopril (2 + 6 mg/kg and (4+12 mg/kg) respectively. The following biochemical and hematological results were recorded during the experiment: Prothrombine Time : Captopril, aspirin and captopril + aspirin treated rats showed significant increase (P < 0.05) in serum PT levels in both T1&T2 subgroups at the period of 1.5 & 3 months treatment positively proportional with the dose and treatment period. Clotting Time: No significant changes were noticed in clotting time of aspirin groups and captopril treated rat groups, while the combined treated subgroups T1&T2 showed a significant increase after 3 month. Blood Urea Nitrogen :Captopril, aspirin and captopril + aspirin treated rats showed significant increase (P < 0.05) in serum BUN levels in both T1&T2 subgroups at the period of 1.5 & 3 months treatment positively proportional with the dose and treatment period. Total Body weight : Significant increase in body weight were observed in captopril, aspirin and captopril + aspirin treated rats in both T1&T2 subgroups through out the experimental periods proportional to the do………..se and treatment periods. | ||
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