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The response to Growth Hormone Therapy in Isolated Growth Hormone Deficiency | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 2, Issue 4, 2009, Pages 409-419 PDF (0 K) | ||
| Authors | ||
| Dr. Sura Y. Noory; Deia K. Kalaf; Refaat M. Abdul Hussain | ||
| Abstract | ||
| objective: to study the response of Growth hormone therapy in children with short stature due to isolated growth hormone deficiency. Sample: six hundred forty eight patient with short stature were enrolled in this study. Method: six hundred forty eight patient with short stature attending Central Teaching Hospital for children Baghdad/ Iraq, were recorded and all patients were investigated to exclude other disease like diabetes, hypothyroidism, celiac disease, turner syndrome, renal failure, achondroplasia,..etc. with a total of 48 patients due to these causes were excluded from the study. So the remaining patients were 600 only those exposed to our study. All children investigated for growth hormone basal level and after provocation by clonidine done for one time . Results: We found that the basal level of growth hormone was less 0.5 microgram (μg)/liter (L), 0.5 -1 μg/liter and more than 1 μg /liter in 25%, 38% and 37% respectively in our sample, while the results after provocation were less than 5, 5-10 and more than 10 μg /liter in 60%, 28% and 12% respectively in our sample. The effect of growth hormone in one year therapy the increment in height was less than 4 cm in 22% of our patients, from 4-8 cm in 50%, and more than 8 cm in 28 % and we found that the male patients were 384(64%), and the female patients were 216(36%),with peak difference between bone age and chronological age was more than 2 year for both sex and most of the patientsُ age was more than 15 years. Conclusion: Most patients with isolated growth hormone deficiency had basal growth hormone level 0.5 – 1μg/L, while the provocation level was less than 5μg/L and the effect of growth hormone therapy on height maximally 4-8 cm in proximately 50% of the patients and more than 8 cm in 28% after one year treatment. Patients with isolated Gh deficiency showed good response to therapy with growth hormone recombinant in a dose 0.1 mg /kg /day | ||
| Keywords | ||
| Growth hormone | ||
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