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The Possible Role of Peripheral Blood Lymphocytes in the Pathogenesis of Diabetes Mellitus….. | ||
| Kerbala Journal of Medicine | ||
| Article 9, Volume 2, Issue 5, 2009, Pages 599-603 PDF (0 K) | ||
| Author | ||
| Haider Sabah Kadhim | ||
| Abstract | ||
| background: Diabetes mellitus (DM) is disorder with world wide distribution with severe complications and high mortality rate. Aim: Our study shed light on the possible role of peripheral blood lymphocytes (PBL) B-cells and T-cells and subsets (T-helper (CD4) and T-cytotoxic (CD8)) in the pathogenesis of DM. Patients and Methods: In this study, 40 patients with type-1 DM, and 40 patients with type-2 DM, with 22 age matched control group were included. Immunocytochemistry for PBL for each group were done to detect the level of B-cell (CD19), T-cell (CD3), T-cell subsets CD4 and CD8. Results: The results showed a significant difference between control group and DM-1 in CD8, while DM-2 showed a significant differences in CD3, CD8 and CD19. A significant difference also seen between type-1 and type-2 DM in CD3 and CD19 markers, while CD4 and CD8 were not significant. Conclusion: This study may explore the role of the immune cells, T-cells (CD3, CD4 and CD8) and B-cells in the pathogenesis of DM especially type -1 DM as it is the prototype of autoimmune disease. | ||
| Keywords | ||
| diabetes mellitus; Type; cell; helper | ||
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