Evaluation of Thyroid function Status in Hemodialysis Patients

F Abdul Mehdi Gamber, Mohammed

	Evaluation of Thyroid function Status in Hemodialysis Patients
Kerbala Journal of Medicine
Article 22, Volume 2, Issue 5, 2009, Pages 716-724 PDF (0 K)
Author
Mohammed F Abdul Mehdi Gamber
Abstract
background The interactions between kidney and thyroid functions are known for years. Thyroid hormones (TH) are necessary for growth and development of the kidney and for the maintenance of water and electrolytes homeostasis. On the other hand, kidney is involved in the metabolism and elimination of TH. Chronic renal failure (CRF) affects thyroid function in many ways, including low circulating thyroid hormone levels, altered peripheral hormone metabolism, insufficient binding to carrier proteins, possible reduction in tissue hormone content and altered iodide storage in the thyroid gland. Thus, patients with renal failure may have various abnormalities of thyroid function; nevertheless, they are typically clinically euthyroid. Objectives: the aim of the present study is to evaluate thyroid function status in patients with hemodialysis in Karbala province, and to determine the benefit of thyroid function test as a routine test requested in hemodialysed patients. Methods: Forty-two hemodialysed patients who attend hemodialysis unit in Al_Hussien teaching hospital in Karbala province with mean age of (44.4±15.9), another 32 apparently healthy subjects with mean age (41.4±12.5) took part in the current study as a control group. An early morning fasting sample of venous blood from each, total trioiodothyronine (TT3), total thyroxine (TT4) and thyroid stimulating hormone TSH were estimated by Enzyme Linked ImmuoSorbent Assay( ELISA). Result: The (TT3) level in haemodialysed patients was significantly lower than the level TT3 in control group (P< 0.001).T-student test reveals no significant difference in the total thyroxine (TT4) level between haemodialysed patients and control group. Also There was no significant difference in the mean level of TSH between hemodialysis and control group. About 41% of haemodialysed patients have TT3 level in the lower tertile of the reference range another 26% have TT3 level below the reference value. There was no correlation between TT3 level in hemodialysis group and duration of hemodialysis (in months). Conclusion: Abnormalities in thyroid function test in hemodialysis patient are more common than that in general population, and low T3 syndrome is considered the main disorder that affect the thyroid function test in hemodialysis patients. So this disorder should be investigated in those patients routinely as, its presence in hemodialysis patients indicates a bad prognosis for them

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