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The role of Matrix Metalloproteinase-2 and -9 with their Tissue Inhibitors in Oral Lichen Planus………………………………………………………………………………………...…….. | ||
| Kerbala Journal of Medicine | ||
| Article 26, Volume 2, Issue 5, 2009, Pages 745-750 PDF (0 K) | ||
| Authors | ||
| er Kassim Al-Kassam; ; Ahlam H. Majeed; Haider S. Kadhim | ||
| Abstract | ||
| Background: Oral Lichen Planus (OLP) is a chronic inflammatory mucosal disease, presenting various clinical forms. Both antigen- specific and non- specific mechanisms involved in the pathogenesis of OLP.Matrix Metallo Proteinases (MMPs) and their inhibitors are one of the mechanisms that would be activated in this disease. Objective: to explore the expression of Matrix MetalloProteinases (2&9) and their inhibitors and correlation between them in oral lichen planus. Method: Twenty five paraffin embedded blocks of OLP and six of sequamous cell carcinoma were collected from the records of Oral Diagnosis Department. Six negative control cases were freshly obtained from Maxillofacial Center in the Specialized Surgeries Hospital in Baghdad. All samples were investigated for the expression of MMPs & Tissue Inhibitors of Matrix MetalloProteinases (TIMP) by Immunohistochemistry (IHC). Results: Expression of MMP-2,-9, TIMP-1 and TIMP-2 were detected at higher significant level in keratinocytes and lymphocytes of OLP cases as compared to control healthy group (p<0.0001). There was no significant difference between the expression of MMP-2, TIMP-1 and TIMP-2 in lymphocytes and keratinocytes. However MMP-9 expression showed significant difference with MMP-2& TIMP-1&-2 in lymphocytes. There was non significant correlation between the expression of MMP-2, MMP-9, TIMP- 1 and TIMP-2; and the morphological types of OLP. Conclusion: High expressions of MMPs and TIMPs in OLP may indicate their role in pathogenesis of the disease as there is no expression of these enzymes in the control healthy; so they could be a diagnostic of aid in OLP. | ||
| Keywords | ||
| Oral Lichen Planus; MMP; TIMP | ||
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