Adiponectin, Insulin and Interlukin-8 in Type-2 Diabetic Obese Patients in Kerbala Province: Iraq ………………………………………………………………………….

H. Al-Khayatt, Tariq; A. Ibraheem, Azher; J. Al-Tu, Fadhil

	Adiponectin, Insulin and Interlukin-8 in Type-2 Diabetic Obese Patients in Kerbala Province: Iraq ………………………………………………………………………….
Kerbala Journal of Medicine
Article 1, Volume 4, Issue 10, 2011, Pages 1047-1056 PDF (0 K)
Authors
Tariq H. Al-Khayatt; Azher A. Ibraheem; Fadhil J. Al-Tu
Abstract
Background: The association between obesity and type-2 diabetes mellitus may be partly mediated by altered secretion of adipokines by adipose tissue. Adiponectin is an adipokines with anti-inflammatory and insulin sensitizing properties; it is secretion is down regulated in obesity. The correlation of plasma adiponectin with the risk of type-2 diabetes mellitus and hyperlipidemia is unclear. Objective: To study the association between plasma adiponectin level with insulin and IL-8, in type-2 diabetic obese patients in Karbala province: Iraq. Material and method: A total number of 110 sample subjects with different age, and different gender were classified according to diabetes mellitus and obesity. Fasting serum adiponectin, insulin and IL-8 were measured by ELISA method. Results: It was obtained that adiponectin level was lowered significantly in diabetic group, obese group, and diabetic obese group as compared with control group. Serum adiponectin was correlated negatively with serum insulin and with body fat percent (BF %), while there was no relation with IL-8 level. Conclusion: According to the presented data, adiponectin as hormone plays an important role in prevention of obesity and insulin resistance, and increase insulin sensitivity.

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