•	Oxidative Stress In Patients With Acute Stroke And Its Effect On Kidney Function

E. Al-Gazally, Moaed; M. Al-Shok, Monem; H. Husein, Ali

	• Oxidative Stress In Patients With Acute Stroke And Its Effect On Kidney Function
Kerbala Journal of Medicine
Article 1, Volume 4, Issue 10, 2011, Pages 1092-1101 PDF (0 K)
Authors
Moaed E. Al-Gazally; Monem M. Al-Shok; Ali H. Husein
Abstract
background: Oxidative stress has been found to be involved in both stroke and renal dysfunction. Aim: In the present study, the relationship of oxidative stress and renal dysfunction after acute stroke was investigated. Patients and Methods: Our study was conducted on seventy four patients with acute stroke and forty one apparently healthy subjects were taken as control group. Patients group was divided into two subgroups, patients with ischemic stroke and patients with hemorrhagic stroke. The sera obtained from the blood of patients and healthy subjects were used to measure the concentrations of malondialdehyde (MDA), glutathione (GSH), creatinine (SCr), and blood urea nitrogen (BUN), and the specific activity of glutathione peroxidase and catalase. Estimated glomerular filtration rate (eGFR) was also calculated. Results and Discussion: The results of this study showed that MAD, SCr, and BUN concentrations were found to be significantly higher, and GSH concentration, GPX and CAT activities, and eGFR levels were found to be significantly lower in acute stroke patients than control group (P < 0.001). Patients with ischemic stroke have significant increase in MDA and SCr concentrations (P< 0.01, P< 0.05, respectively), and significant decrease in GSH concentration , GPX and CAT activities, and eGFR levels (P< 0.05, P< 0.05, P< 0.01, P< 0.01, respectively) than patients with hemorrhagic stroke. Our results also showed the presence of highly significant positive correlation between MDA concentration and BUN and SCr concentrations, and highly significant negative correlation between MDA concentration and eGFR levels. Inversely there was highly significant negative correlation between measured antioxidants levels and BUN and SCr levels, and highly significant positive correlation between measured antioxidants and eGFR levels. According to the results of our study we found that acute stroke is associated with elevated oxidative stress, kidney function is significantly compromised in patients with acute stroke, acute kidney injury (AKI) is a common complication after acute stroke, and there was highly significant correlation between oxidative stress in patient with acute stroke and decline in kidney function. Conclusion: The kidney function in patient with acute stroke may be directly or indirectly affected by the level of oxidative stress developed during the acute phase of disease and there was a cerebro-renal connection, which is disease that affects brain may also affect kidney and vice versa.

Statistics Article View: 118 PDF Download: 113