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Clinical, Biochemical and Histopathological outcome of six months of Interferon therapy in thalassemic patients with chronic hepatitis C viral infection | ||
| Kerbala Journal of Medicine | ||
| Article 3, Volume 1, Issue 2, 2007, Pages 190-196 PDF (0 K) | ||
| Authors | ||
| Sayah H. A; Ghadban J. M | ||
| Abstract | ||
| background: Hepatitis C viral infection is a common cause of liver disease among polytransfused patients. Aim of the study: To find out short term efficacy of Interferon therapy in thalassemic chronic viral hepatitis-C patients. Setting: This study was carried out in Gastroenterology and Hepatology Teaching hospital in Baghdad – Iraq Patients and methods:Twenty four thalassemic patients who were anti HCV antibody positive with elevated liver enzyme for more than one year enrolled in this study . All patients were submitted to liver biopsy to assess the degree of the inflammation and fibrosis .All patients were treated with interferon alpha (3 ×106 units/m2) tree times a week for six months. Result: Three out of twenty four patients stopped treatments because of sever side effect. Out of twenty one patients; 10(47 %) of patients showed complete biochemical response, 7(33%) of patients showed partial biochemical response, 4(19%) of patients showed no response. Young age patients responded better to interferon therapy .patients with initial high serum alanine trasaminase responded less favorably than those who had lower initial pretreatment serum alanine transaminase ,this was statistically significant .The higher the initial serum ferritine the worst the biochemical and histological response .All patients who responded biochemically and submitted to another liver biopsy showed decrease in severity of histological activity index after six months of Interferon therapy ;there was strong correlation between biochemical response and histological response. There was no improvement in degree of fibrosis in those treated with interferon therapy.Splenectomized patient tolerated better and responded better than those who were not splenectomized . Conclution:Thalassemic patients with chronic viral hepatitis C can benefit at least in short term from Interferon therapy especially in younger age patients and those who have lowest elevation of liver enzymes and those with lower serum ferritin level. Keywords:Hepatitis,Hepatitis C,Thalassemia,Thalassemic patients ,Interferon | ||
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