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The Effect of Combined Administration of Fish Oil with Garlic to Lower Cholesterol in Hypercholesterolemic Subjects (Comparative Study) | ||
| Kerbala Journal of Medicine | ||
| Article 7, Volume 1, Issue 2, 2007, Pages 217-224 PDF (0 K) | ||
| Authors | ||
| L. J; ; Abdil Razzak | ||
| Abstract | ||
| background: Garlic and its preparations have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. Elevated total cholesterol, especially low-density lipoprotein has been documented as the leading risk factor for the coronary artery disease. Studies with fish oil supplementation alone have shown an increase in low-density lipoprotein, thereby enhancing the risk associated with incidence of coronary artery disease in hypercholesterolemic subjects. In view of this, the effect of a combined supplementation of fish oil with garlic pearls on the serum lipid profile of hypercholesterolemic subjects was studied. Methods and Results: We administered 600 mg of fish oil with 500 mg of garlic pearls (garlic oil) per day to 16 hypercholesterolemic subjects with a total cholesterol above 220 mg/dl for 60 days. The effect of this combined supplementation was compared with group that administered 500mg garlic only per day to 16 hypercholesterolemic subjects with a total cholesterol above 220 mg/dl for 60 days also while the comparison done with garlic group(16 hypercholesterolemic subjects) that take only garlic and with a control group (16 hypercholesterolemic subjects) without any supplementation. Significant reductions were seen in all the lipid parameters (except high-density lipoprotein which was increased) in the test groups after 60 days compared to that of the control group. The total cholesterol, low-density lipoprotein, serum triglyceride, very low-density lipoprotein, and the total cholesterol: high-density lipoprotein ratio reduced significantly. | ||
| Keywords | ||
| Garlic; coronary artery disease; Hypercholesterolemia; Fish oil | ||
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