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Attenuated LaSota Virus Vaccine with a Urtica Pilulifera Extract In Treatment of Mammary adenocarcinoma in Mice | ||
| Kerbala Journal of Medicine | ||
| Article 9, Volume 1, Issue 2, 2007, Pages 236-242 PDF (0 K) | ||
| Authors | ||
| A. O; | ||
| Abstract | ||
| background: The attenuated Newcastle Disease Virus (NDV) vaccine LaSota strain has been found to cause regression in volume of mammary adenocarcinoma transplanted subcutaneously in mice when injection locally (intratumoral) with Urtica pilulifera orally. The growth inhibition at the end of experiment was (77%) and statistically significant compared with the tumor volume in untreated group. While the growth inhibition in the group treated intraperitonealy (I.P) was (28%).The relative tumor volume was decreased in the group treated with virus (I.T) but increased in group treated (I.P) comparing with the tumor size at the begining of treatment. Histopathologically , there was an extensive area of necrosis and replacement by granulation tissue with mononuclear cells infiltration (lymphocytes, plasma cells and macrophages). | ||
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