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Serum Concentration of Choline Esterase in Chronic Liver Diseases | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 25, Issue 2, 2012, Pages 158-160 | ||
| Author | ||
| Faisal Gh. Al-Rubaye | ||
| Abstract | ||
| Background: In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation, Chronic liver disease is a health problem that results in the progressive destruction and deterioration of the liver. The disease, which develops at a slow process, lasts for a long period of time; there are various types of chronic liver disease. One of them is cirrhosis of the liver. Aim: to assess the status of Choline esterase in patients with various chronic liver diseases. Subject and methods: the present study is a cross-sectional study at Al-Yermouk Teaching Hospital. Include measurement of serum Choline esterase in patients with different chronic liver diseases. Results: a total of 110 patients with chronic liver diseases were involved in this study, they were classified as following: o Patients with hepatitis G1: (n=30). o Patients with hepatic cirrhosis G2: (n=30). o Patients with hepatic carcinoma G3: (n=30). o Patients with hepatic carcinoma receiving chemotherapy G4: (n=30). A matching group of apparently healthy subjects who were included as controls G5: (n=60). Serum choline esterase was significantly reduced in patients with chronic liver diseases as compared with the controls (p < 0.001) with the lowest reduction in hepatic carcinoma group (G3). Conclusion: patients with chronic liver diseases have low level of serum choline esterase compared with controls as a part of impairment of hepatic function; however, this reduction was not severing enough to cause neuromuscular blockade, the above results were supported by the significant low level of s. choline esterase; which can be used to monitor hepatic function. Key words: choline esterase, chronic liver diseases. | ||
| Keywords | ||
| choline esterase; chronic liver diseases | ||
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