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Celiac disease is a member of oxidative stress syndrome | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 22, Issue 2, 2009, Pages 88-91 | ||
| Author | ||
| Waleed M. Al-Mashhadani | ||
| Abstract | ||
| Background: celiac disease is an intestinal disorder with multifactorial etiology. Little is known about its relation with oxidative stress. Objective: This study was designed to show that celiac disease is a member of oxidative stress syndrome through measuring some of its markers. Design: sixteen adult patients with celiac disease were studied with 20 healthy control subjects matched by age. All were attending for upper gastrointestinal endoscopy and they underwent a small intestinal biopsy to confirm or overrule suspicion of celiac disease. Celiac patients were graded according to the marsh score. Fasting serum malonldialdehyde (MDA), uric acid, total albumin and creatinine were measured as a marker of oxidative stress. Results: serum levels of MDA were significantly higher in celiac patients in comparison to that of controls (5.363±0.737 V.S 4.335±0.511 respectively) (p <0.05). The results showed that celiac patients with high MDA level had more marked histological changes. Serum levels of total albumin and creatinine were low while serum uric acid was little bit higher than that of controls without reaching significant levels. Conclusion: The results indicated that celiac disease is a member of oxidative stress syndrome, and the result may open a new line of treatment of celiac patients with antioxidants. Key wards: celiac disease, oxidative stress, MDA, free radicals, total albumin. | ||
| Keywords | ||
| celiac disease; Oxidative stress; MDA; free radicals; total albumin | ||
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