Objectives: To assess whether the pre-pregnancy maternal body mass index (BMI in kg/m²) was associated with the use of antiemetic drugs in early pregnancy and or with hospital admission for hyperemesis gravidarum (HG).
Study design: Prospective observational study.
Patients methods: one hundred and fifty pregnant patients were included in this study , had been seen at there booking visit they were ,not smoker , at least complete their primary school ,know there weight prior to pregnancy, pregnant with singleton viable intrauterine pregnancy . Full history , clinical examination and measurement of their BMI(kg/m) then divided in to four groups, According to WHO classification of BMI patients were four groups : <18.5 kg/m² (under weight) ,18.5-24.9kg/m² (normal weight) ,25-29.9kg/m² (over weight) ≥30kg/m² (obese), The patients keep on regular follow up ,and informed to return once sever nausea and vomiting developed(nvp) that sever required medication and when hospital admission is indicated for hyperemesis gravidarum(HG).
Result: Underweight women were significantly used antiemetic drugs in early pregnancy p value <0.02 , relative risk(RR)= 1.54 and confidence interval (CI 95%) = 1.o5-2.26 and become significantly hospitalized for hyperemesis gravidarum (HG) P value < 0.02 ,with RR = 2.17 and (CI 95%) =1.10-4.26 compared to ideal weight women, Obese women were significantly used less antiemetic drugs P value <<0.04 , RR= 0.49 and CI(95%) =0.24-0.97,and required hospitalization for (HG) less, but not reach the level of significance P value< 0.05 , RR= 0.14 , CI(95%) = 0.018-1.03 compared with ideal weight women, No statistical significant difference was found between over weight women compared with ideal weight women regarding antiemetic drugs used and hospitalization.
Conclusion: The used of anti emetic drugs and HG required hospitalization significantly more in women with under weight.
Key words: BMI, hyper emesis gravid arum, nausea and vomiting of pregnancy. |