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Histological Changes of Gall Bladder Mucosa: Correlation with Various Types of Cholelithiasis | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 24, Issue 3, 2011, Pages 234-240 | ||
| Author | ||
| Muna Zuhair | ||
| Abstract | ||
| Background & Objective: The aim of this study is to investigate the histological changes of gall bladder mucosa in relation to different gallstones whether it was cholesterol, pigment or mixed stone. Patients and Methods: Thirty specimens of gallbladders collected from patients who underwent cholecystectomy, Paraffin sections were stained with haematoxylin and eosin to demonstrate the general histology while Periodic acid-Schiff and Alcian blue were utilized to evaluate the intraepithelial mucin content. Results: The histological changes were found to be more obvious in gall bladders with cholesterol stones, except the muscular hypertrophy which was more prominent in gallbladder with pigment stones. The mucosal hyperplasia in gall bladders with cholesterol stones was found in 26.6% of cases, Roktansky-Aschoff sinuses in 13.3% of cases, distended columnar cells were found in 23.3%, mucous gland metaplasia was found in 10% of cases while lymphatic cells infiltration and haemorrhage with congestion both were found in 26.6% of cases. The neutral mucopolysaccharides and sulfate acid mucopolysaccharides were increased in the basement membrane and found to be more prominent in gall bladders with cholesterol stones than in pigment and mixed stones. Conclusion: Gallstones are accompanied by major changes in the gallbladder epithelium. These changes were clearer in gallbladder mucosa with cholesterol stones may be due to the large size stones leading to more irritation to the mucosa in addition to the toxic effect of the lithogenic bile which produce chemical injury to the mucosa. Key Words: Gallbladders, Cholesterol stone, Roktansky-Aschoff sinuses. | ||
| Keywords | ||
| Gallbladders; Cholesterol stone; Roktansky; Aschoff sinuses | ||
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