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Genetic polymorphisms of GSTM1 and GSTT1 Genes and Endometrial Cancer in Basrah, south of Iraq | ||
| Journal of Basrah Researches (Sciences) | ||
| Article 1, Volume 37, Issue 5, 2011, Pages 54-59 PDF (0 K) | ||
| Author | ||
| Adnan Issa Al-Badran | ||
| Abstract | ||
| The genes glutathione S- transferase M1 (GSTM1) and GSTT1 involved in phase II metabolism catalyse glutathione – mediated reduction of exogenous and endogenous electrophiles. A case control study was designed to identify the association between polymorphisms at GSTM1 and GSTT1 genes and endometrial cancer risk. While there was a lack of association between GSTM1 null genotype with the risk of endometrial cancer, the null genotype of GSTT1 had a 5.7 fold increased risk toward endometrial cancer (OR=5.76; 95% CI = 2.07-15.97). Both GSTM1, GSTT1 null genotype increased risk to about 3 fold. When stratified according to different grades of endometrial cancer the GSTM1 was more representative in grade III (OR=2.6), the association becomes stronger when the GSTT1 gene was also null (OR= 4.6). | ||
| Keywords | ||
| endometrial cancer; genetic polymorphism; glutathione S; transferase | ||
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