Factor XII level in patients with acute Myocardial Infarction

Mudhafar Zubair Al-Qasim, Aladdin

	Factor XII level in patients with acute Myocardial Infarction
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 24, Issue 1, 2011, Pages 25-29
Author
Aladdin Mudhafar Zubair Al-Qasim
Abstract
Background: Acute myocardial infarction (AMI) is one of the most common diagnoses in hospitalized patients in industrialized countries. Factor XII is one of the contact activation factors. Hageman factor (FXII) activates coagulation through the intrinsic pathway. It concurrently activates the fibrinolytic system. This mechanism exists to limit clotting by cleaving fibrin, thereby solubilizing the fibrin clot. Aims of the study: To study the level of intrinsic coagulation factor (FXII: C) in patients with acute myocardial infarction. Subjects, Materials and Methods: Thirty patients were included in this study (9 female, 21 male) that were just admitted to the Coronary Care Unit in Al-Yermouk Teaching Hospital and diagnosed as having acute myocardial infarction. Blood samples were taken from these patients. Their age range is 48-68 years. Thirty healthy subjects (9 female, 21 male) age and sex matched with the patients were included as a control group. FXII: C activity was assayed for both patients and control groups. Statistical Methods: The student T-test and correlation study were used for statistical tests. Results Mean FXII: C (71.03±11.46) is significantly (P value <0.001) lower in acute myocardial infarction group than control group (119.00%±8.52). Conclusion FXII: C level was significantly lower in patients with acute myocardial infarction than control group. Key words: acute MI, factor XII assay
Keywords
acute MI; factor XII assay

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