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Evaluatoin of Two Inactivated Newcastle Disease Vaccines in Broiler Chicks | ||
| iraqi poultry sciences journal | ||
| Article 1, Volume 4, Issue 1, 2009, Pages 75-80 | ||
| Author | ||
| Bushra Hamza Faris | ||
| Abstract | ||
| Alum precipitated killed ND vaccines are prepared from the allantoic fluid (AF) and from homogenized whole embryo (WE). Efficacy of these two vaccines has been evaluated in chickens by using local velogenic strain in its preparation . Fifty chicks one day old were divided into three groups:- the first (Group –A) consist of 20 chicks , the second (Group-B) consist of 20 chicks and the third (Group- C)consist of 10 chicks as control. Each chick of group A and B was inoculated with 0.025ml live lentogenic ND vaccine (La Sota –strain) containing 107.5 EID50/0.1 ml by intraocular route at day one of age ,whereas , chicks of group C was left unvaccinated as control. Each chick of group A and B was injected at 7 days of age with prepared inactivated vaccines of ND via subcutaneous route as 0.5 ml containing 108.5 ELD¬¬50 / 0.1 ml and 108.3 ELD¬¬50 / 0.1 ml for (AF) and (WE) respectively. The mean values of Haemagglutination Inhibition (HI) antibody titres in both groups A and B were found significantly increased (P<0.01) after two weeks of primary vaccination with live attenuated vaccine and three weeks of last vaccination with inactivated vaccine, and also two weeks of post challenged infection in comparison to the respective pre- vaccination values. The result of challenge revealed that one (5%) chick of group- A, two (10%) chicks of group- B, died in the third day post- challenged, whereas, 10 (100%) unvaccinated control chicks of group- C died within 1 to 3 days post challenged. Therefore, the vaccine prepared from AF group-A gave a protection to 95% and whole embryo WE vaccine of group- B gave a protection to 90% of vaccinated chicks against challenged infection. This indicates that, these prepared ND vaccines induced sufficient humoral antibody titres against virulent ND, which was used in the challenge test. Therefore, the present experiment recommend to use these prepared vaccines in vaccination program to control ND infection in Iraq . | ||
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