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Histological Changes in the Thoracic Aorta of Adult Rats Treated with Melatonin | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 24, Issue 2, 2011, Pages 168-173 | ||
| Authors | ||
| Sameh S. Akkila; Samia A. Eleiwe; Emad G. Qassem; Hayder H. Abdulateef | ||
| Abstract | ||
| Background: The main pineal hormone, Melatonin, is an important cardioprotective hormone whose receptors have been located in the vasculature & have been suggested to inhibit vascular reactivity through different mechanisms. It can prevent the initiation & the progression of atherogenicity. Objective: the study aims to explore the histological effects of pharmacological & high doses of dietary melatonin on the thoracic aorta of adult rats. Materials & Methods: melatonin was given to adult albino rats for successive 4 weeks at daily single doses ranging from 250-1000 µg / kg body weight. The thoracic aorta was then studied under light microscopy for histological changes. Results: Studied specimens showed that 250 µg / kg body weight doses didn’t cause a significant change in the histology of the vasculature while 500 µg / kg body weight doses resulted in significant but regular vascular thickening. The high doses resulted in irregular smooth muscle hyperplasia, disruption of the connective tissue patterns & signs of intimal injuries. Conclusion: Low doses of melatonin may be protective & supportive to the vasculature but higher doses carry the risk of vascular damage. Key Words: Melatonin, vasculature, thoracic aorta, smooth muscle hyperplasia. | ||
| Keywords | ||
| Melatonin; vasculature; thoracic aorta; smooth muscle hyperplasia | ||
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