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The Effect of Hormonal Male Contraception on Sertoli-germ Cell Interaction in Albino-mice Testes: Morphological Study | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 22, Issue 3, 2009, Pages 201-205 | ||
| Author | ||
| Abd Al-Jabber Falih Hussein | ||
| Abstract | ||
| Background: The Sertoli cells have special adhesive junction called ectoplasmic specialization make the adhesion between the Sertoli and germ cells ,there are also adhesive proteins which are produced under Follicle stimulating hormone and testosterone hormone control ,these junctions are important in translocation of germ cells through the epithelium toward the lumen . Objective: To study the effect of hormonal male contraception on Sertoli-germ cell interaction. Materials & Methods: 20 adult male albino mice mus musculus were used and divided into two groups :treated and control groups ; the treated group include 10 mice receive weekly intramuscular injection of 10 mg/kg of medroxyprogesterone acetate (as hormonal male contraception) and testosterone enanthate to keep testosterone level within physiological level ,while control group receive 0.1 ml of normal saline . Results: The histological examination of treated testes reveal disorganization of the seminiferous epithelium with loss of adhesion between cells and some cells are sloughed into the lumen with formation of gap around the germ cells due to shrinkage of Sertoli cells. Conclusions: Hormonal male contraception affects the production of adhesive proteins between sertoli and germ cells with disorganization of Sertoli cell cytoskeleton which leads to spermiation failure and germ cell sloughing and detachment. Key words: Spermatid sloughing, spermiation failure, ectoplasmic specialization, hormonal male contraception | ||
| Keywords | ||
| Spermatid sloughing; spermiation failure; ectoplasmic specialization; hormonal male contraception | ||
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