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Serum Ribonuclease Level (RNase) as Tumor Marker in Patients with Thyroid Cancer | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 21, Issue 2, 2008, Pages 133-138 | ||
| Author | ||
| Manal Kamal Al-Ani | ||
| Abstract | ||
| Back ground: Evidence is presented to show that most patients with thyroid cancer have an increased level of serum RNase, assayed with the synthetic compound, (yeast RNA). In addition, the results suggest that the enzyme level may be useful indicator of response to chemotherapy with I131. Preliminary results of enzyme levels in the serum of patients with thyroid cancer that was high are due to excessive entry of RNase into the serum. Objective: 1- measure RNase levels in serum of patients with thyroid cancer, and to point out any relationship with these disease by comparing its level with that of healthy individuals (control group). 2-Study the possibility of using RNase as a tumor marker for thyroid cancer. Subjects and Methods: A total of 100 subjects were enrolled in this study, they were 50 healthy individuals (control group) and 50 patients with thyroid cancer (patients group). The thyroid cancer patients treated by surgery and with or without radioactive iodine 131. The latter subdivided into three other subject groups categorize according to the remnant tissue after thyroidectomy. The method it is possible to measure the RNase reaction by observing in absorbance of UV light of wavelengths at 260 nm in reaction solution, the rate of hydrolysis of yeast RNA at PH 7.6 is determined by measuring the amount of acid soluble oligonucleotide librated under defined condition. Results: There was a significant elevation in serum RNase leveling patients with thyroid cancer as compared to healthy individual's control, while the level of serum RNase in patients after thyroidectomy decrease deepened on the remnant tissue after surgery and who exhibited clinical response to radioactive iodine therapy. Conclusion: This simple available method might aid to use it as a biochemical marker in detection and follow up during treated of thyroid cancer. Key word: Thyroid cancer, RNase. | ||
| Keywords | ||
| Thyroid Cancer; RNase | ||
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