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Histological modulation of adult rat's testis in response to anti-aging factor | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 21, Issue 2, 2008, Pages 120-125 | ||
| Author | ||
| Samia A. Eleiwe | ||
| Abstract | ||
| Background: Melatonin overtops other hormones in the studies of hormonal – replacement therapy nowadays. It is an anti-aging and antioxidant, prevents the oxidative damaging events to endocrine organs including testis. Objective: The on going study tried to document that the fertility of testes must be increased by melatonin supply within the therapeutic doses. Methods: Melatonin was supplied to adult male albino rats, for successive 14 days. Rats were divided into 6 groups. Group I was the control. Group II, III, IV, V and VI were given melatonin as a daily dose of 125, 250, 500, 750 and 1000 µg / kg body weight, respectively. After the last day of treatment, animals were killed under effect of anesthesia. Left testis was studied to evaluate the fertility status. Result: The results showed significant increase in the reproductive morphology with the therapeutic doses, while highly degenerative changes seen with larger doses. Conclusion: Melatonin increases the reproductive morphology of rat's testes within therapeutic doses, whereas it induces vast damages with large doses. Key Words: Testis, melatonin, antiaging, and hormonal replacement therapy | ||
| Keywords | ||
| Testis; Melatonin; antiaging; and hormonal replacement therapy | ||
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