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The Possible Role of C-Myc and P-53 on the Pathogenesis of Transitional Cell Carcinoma of the Bladder | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 22, Issue 4, 2009, Pages 254-259 | ||
| Authors | ||
| Basim H. Bahir; Wasan A. Baker; Amal H. Salman | ||
| Abstract | ||
| Objective: Estimation of the in situ hybridization expression of c-Myc mRNA and immunohistochemistry expression of p53 protein in patients with transitional cell carcinoma of the bladder. Methods: A technique utilizing in situ hybridization was performed to detect c-Myc mRNA and immunohistochemistry technique was performed to detect p53 proteins using paraffin embedded sections of tissue that were obtained from 60 patients; who were divided into two groups: 30 patients with transitional cell carcinoma of the bladder (group 1) and 30 cystitis patients as a control group( group2 ). Patient's ages ranged between 25-81 years (14 females and 46 males). Results: The levels of the in situ expression of c-Myc mRNA and immunohistochemistry expression of p53 were found to be highly significantly increased in group 1 as compared with group 2 (P<0.001),with a significant positive correlation between these two parameters (P<0.05) in group 1 and 2. Conclusion: The results of this study indicated that c-Myc gene and p53 protein may play an important role in pathogenesis of bladder cancer and the expression of c-Myc was associated with expression of p53 in patients with bladder cancer. Key word: Bladder cancer, p53, c-Myc | ||
| Keywords | ||
| Bladder cancer; Myc | ||
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