Study of Microalbuminurea in Hypertensive, Type 2 Diabetic Patients

F. R. AL-Auqbi, Tawfeeq; Tha, Noor; Tahir Al-Khalidy, Ir

	Study of Microalbuminurea in Hypertensive, Type 2 Diabetic Patients
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 23, Issue 1, 2010, Pages 14-18
Authors
Tawfeeq F. R. AL-Auqbi; Noor Tha; ir Tahir Al-Khalidy
Abstract
Objectives: To study the importance of early diagnosing microalbuminurea in hypertensive, type 2 diabetic patients and its relation to different parameters. Patients & Method: Thirty nine hypertensive, type 2 diabetic patients were studied in two groups according to the presence of microalbuminurea; 20 patients with microalbuminurea (case group) and 19 patients without microalbuminurea (control group). CLINITEK® Microalbumin kit, reagent strips for determining albumin and creatinine in Urine, was used to isolate patients with microalbuminurea. Patients’ BMI and blood pressure were measured; also investigations for FPG, HbA1c, total cholesterol, triglyceride, HDL, LDL, VLDL, B. Urea and S. Creatinine were done. Urine samples were examined for presence of pus cells, overt albuminurea, levels of albumin, creatinine and Albumin/Creatinine ratio. Results: Male/female ratios of the case and control groups were 1/1.22 and 1/0.58 respectively. The mean of age, BMI, duration of disease, frequency of medical consultation per year and systolic / diastolic blood pressure showed insignificant statistical differences (t-test, P > 0.05) between case and control groups. The mean of lipid profile components, total cholesterol, triglyceride, HDL, LDL and VLDL showed insignificant statistical differences (t-test, P > 0.05) between case and control groups. Moreover mean of biochemical investigations for FPG, HbA1c, B. Urea, S. Creatinine and creatinine level in urine showed insignificant statistical differences (t-test, P > 0.05) between case and control groups. Conclusions: Early detection of albumin in urine at level 30 to 300 mg/d in a 24-h collection of urine or 30 to 300 µg/ mg creatinine in a (overnight) spot collection (microalbuminurea) is the only important and reliable predictive test for diagnosis of diabetic nephropathy. Conduct periodic routine investigation of urine for microalbuminurea, for all hypertensive diabetic patients even the newly diagnosed diabetics, to detect early stage of diabetic, incipient, nephropathy and consult nephrologists to start strict and intensive treatment throughout the reversible stage of diabetic nephropathy. Nephrology consultation should be considered after the diagnosis of early incipient nephropathy .There is good evidence that early treatment delays or prevent s the onset of diabetic nephropathy. Key Words: Hypertension, type 2 diabetes mellitus, albuminurea, creatinine, lipid profile.
Keywords
Hypertension; Type; albuminurea; creatinine; Lipid profile

Statistics Article View: 138 PDF Download: 14