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Spectroscopic Photoluminescence of Quantum Dots for Cancer Biomarker Panels | ||
| Iraqi Journal of Applied Physics Letters | ||
| Article 1, Volume 2, Issue 4, 2009, Pages 33-36 | ||
| Authors | ||
| N. Korsencka; S. Ostepanko; M. Dypiec; L. Zukov | ||
| Abstract | ||
| Ovarian cancer is the most lethal gynecologic malignancy. This largely reflects the fact that approximately 75% of cases are detected at advanced stages of disease, when cure is unlikely. It is accepted that detecting a greater number of patients with early stage disease by improving screening modalities could significantly improve overall survival. A novel approach to increase the sensitivity and specificity of early detection of cancer is through the application of nanotechnology, where luminescent semiconductor quantum dots (QDs) are conjugated with biomolecules. We report on the luminescence characterization of the bio-conjugated QDs with CA125 antigen using linkage molecules. Kinetic curves of the bio-conjugated 655nm QD luminescence show both photoenhancement and photo-degradation. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths. The mechanism of the PL enhancement is discussed. | ||
| Keywords | ||
| Spectroscopy; Photoluminescence; Quantum dots; Cancer Biomarker Panels | ||
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