Drugs combination in total intravenous anesthesia Propofol-ketamine Vs. propofol-fentanyl

Haki Ismael, Ahmed

	Drugs combination in total intravenous anesthesia Propofol-ketamine Vs. propofol-fentanyl
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 24, Issue 4, 2011, Pages 318-324
Author
Ahmed Haki Ismael
Abstract
Background: Keeping in consideration the benefits of total intravenous anesthesia (TIVA), a genuine attempt was made to find the ideal drug combination which can be used in general anesthesia. Objectives: This study was conducted to evaluate and compare two drug combinations of TIVA using propofol-ketamine and propofol-fentanyl and to study the induction, maintenance and recovery characteristics following anesthesia with these techniques. Patients and Methods: A case comparison study (Clinical Trial) was conducted, which included 100 patients, which randomly allocated in two equal groups. A hundred patients between the ages of 20 and 50 years of either gender were divided into two groups of 50 each, and they underwent elective surgery of approximately 1 hour duration. Group K received propofol-ketamine while group F received propofol-fentanyl for induction and maintenance of anesthesia. All the results were tabulated and analyzed statistically with student's unpaired t-test and chi-square test. Results: Propofol-fentanyl combination produced a significantly greater fall in pulse rate (PR; 9.28% versus 0.23%) and in both systolic (7.94% versus 0.12%) and diastolic blood pressures (BP; 8.10% versus 0.35%) as compared to propofol-ketamine during induction of anesthesia. Propofol-ketamine combination produced stable hemodynamic during maintenance phase while on the other hand propofol-fentanyl was associated with a slight increase in both PR and BP. During recovery, ventilation score was better in group K while movement and wakefulness score was better in group F. Mean time to protrusion of tongue and lifting of head was shorter in group K. Conclusion: Both propofol-ketamine and propofol-fentanyl combinations produce rapid, pleasant and safe anesthesia with only a few untoward side effects and only minor hemodynamic effects. Keywords: Propofol-ketamine, propofol-fentanyl, total intravenous anesthesia
Keywords
Propofol; ketamine; Propofol; fentanyl; total intravenous anesthesia

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