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Synthesis and Study of Some New Mannich Bases Derived From Isatin (1H - Indole – 2, 3 – Dione ) with Substituted Sulfonamides and Their Antimicrobial Activity | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 2, 2012, Pages 40-45 | ||
| Author | ||
| Khalaf Ahmed Jasim AL- Bayati | ||
| Abstract | ||
| A series of new amino – alkylated Mannich bases were prepared by reaction of substituted sulfonamides with formaldehyde and isatin (1H- indole – 2, 3- dione). Mannich bases 4(f-j) were prepared by reaction of isatin with formaldehyde and secondary amines. The structure of the newly synthesized compounds was confirmed by melting points, TLC, and FTIR, 1H-NMR spectral data. All the newly synthesized Mannich bases are introduced for antimicrobial activity against the bacteria: B.subtillis , E.coli and K. pneumoniae. All the Mannich bases showing better antibacterial activity to the corresponding sulfonamides, and therefore the results obtained showed available attempt for the drugs building. | ||
| Keywords | ||
| Isatin; Substituted Sulfonamides; Mannich bases; Antimicrobial activity | ||
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