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SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITIES OF2,6-DIARYLPIPERIDONE –y-DERIVATIVES | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 53, Issue 3, 2012, Pages 465-478 | ||
| Authors | ||
| Kh. Hamak; S. Hamo; | ||
| Abstract | ||
| In the present study new series of2,6-diarylpiperidones-4 derivative were synthesized and these compounds are : 1-(1-oxo-2-chloro-ethyl)-3,3-dimethyl-2.6-diarylpiperidone-4(I) 1-(1-oxo-2-chloro-ethyl)-3.5-dimethyl-2,6-diarylpiperidone-4(II) 1-(1-oxo-2-imidazolyl-ethyl) -3,3-dimethyl-2,6-diphenyl piperidoe-4(III) 1-(1-oxo-2-imidazolyl-ethyl)-3,5-dimethyl-2,6-diphenylpiperidoe-4 (IV) The prepared compounds were characterized by IR,LC-MS and 1H,13C-NMR spectra .All compounds were screened for their antibacterial activity against gram positive bacteria :Bacillus subtilis and gram negative bacteria :Escherichia coli at different concentration (1000, 500, 250, 100) ppm. These compounds show good activity against gram positive more than gram negative bacteria | ||
| Keywords | ||
| piperidone; imidazole; antibacterial activity; coli; Bacillus subtilis; Escherichia coli; Bacillus subtillus | ||
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