The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction

Esmaeel Ibrahim, LmmmA; Dhafer EL-Yassin, Hadef; Kareem Sachit AL-Janabi, Hamid

	The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction
Iraqi Postgraduate Medical Journal
Article 1, Volume 11, Issue 4, 2012, Pages 536-541 PDF (0 K)
Authors
lmmmA Esmaeel Ibrahim; Hadef Dhafer EL-Yassin; Hamid Kareem Sachit AL-Janabi
Abstract
ABSTRACT: BACKGROUND: Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein (CRP) is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 (IL-6), a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of acute-phase proteins. OBJECTIVE: The present study was designed to examine the relationship between fasting plasma IL-6 and CRP concentrations and insulin action in acute myocardial infarction patients. SUBJECTS AND METHODS: The study included 50 patients with acute Myocardial infarction (AMI) and forty healthy subjects as control group. Levels of insulin, CRP and IL-6 were measured. RESULTS: The levels of insulin, IL-6 and CRP were significantly elevated in AMI patients with (p<0.001). There was positive correlation between insulin with CRP and IL-6 in acute myocardial infarction patients. CONCLUSION: The significant increase in insulin in AMI may be related to inflammation. Insulin positively correlated with inflammatory markers (CRP and IL-6)
Keywords
Insulin; CRP; acute myocardial infarctio

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