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VCAM-1 Expression in Endometerium with Human | ||
| Al-Kindy College Medical Journal | ||
| Article 1, Volume 8, Issue 1, 2012, Pages 14-17 | ||
| Authors | ||
| ; Manal Adnan Habib MBChB; ; Shatha Al-ZuhairyMBChB; ; Asmaa B Al-Obaidi MBChB | ||
| Abstract | ||
| Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules. Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule. Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively). Conclusion: HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the surface expression of pro-inflammatory adhesion molecules like VCAM-1. Key wards: human cytomegalovirus, VCAM-1, Abortion | ||
| Keywords | ||
| human cytomegalovirus; VCAM; abortion | ||
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