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IL-10 serum level estimation in Iraqi colorectal and gastric cancer patients | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 54, Issue 2, 2012, Pages 167-171 | ||
| Author | ||
| Ahmed R. Abdulla | ||
| Abstract | ||
| Background:Gastrointestinal cancers (GITc) is a worldwide problem. In Iraq , Gastric cancer is the 9th commonest of the top cancers while colorectal cancers it is considered as the 7th commonest ten cancers.IL-10 appears to be more of a pro-tumor than anti-tumor properties in both colorectal and gastric cancers. Objective:is to estimate the serum level of IL-10 in the Iraqi colorectal and gastric cancer Patientsand its relation to the progress of disease. Patients and Methods:In ourstudy ,54 serum samples werecollected starting from the 1st of January to mid of March 2011, to investigate the IL-10 serum level by using ELISA kit. 38colorectal and gastric cancer patients (H.Pylori +ve) and 16 of healthy control group. Results: The results showed that IL-10 serum levels of both GIT tumors were increased significantly (p<0.05) comparing with the healthy control group. Conclusion:In conclusion, the high serum level of IL-10 in colorectal cancers is due to the pro-tumor properties of IL-10 while in gastric cancer while the association of IL-10 genotypes specifically the single nucleotide polymorphism of the IL-10 promoter region may be the source of its serum increasing level. Keywords: IL-10, Colorectal Cancer, Gastric Cancer. | ||
| Keywords | ||
| Colorectal cancer; Gastric Cancer | ||
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