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MicroRNA 210 expression profile from human placentas of preeclamptic | ||
| Mustansiriya Medical Journal | ||
| Article 1, Volume 11, Issue 2, 2012, Pages 29-33 | ||
| Author | ||
| Miami A. Ali FICOG | ||
| Abstract | ||
| Background: Pre-eclampsia (PE) is a common pregnancy specific syndrome that is characterized by hypertension and proteinuria. Evidence shows that pre-eclampsia is associated with alterations in placental microRNA expression. Aims: The purpose of this study was to compare the expression of the microRNA 210 in placentas from preeclamptic pregnancies versus normal placentas. Patients and Methods: The study was carried out in the department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital for the period from December 2009 to December 2010. Hundred pregnant women of age ranging from fifteen to forty years old, their gestational age ranging between twenty nine to forty weeks were divided into three groups: first group: mild Pre-eclampsia (twenty), second group: severe pre-eclampsia (thirty) & third group (fifty) normotensive pregnant women of comparable gestation were taken as a control . After delivery the Placentas from all patients (the study and the control groups) were obtained and studied for the microRNA 210 expression which was assessed by microRNA microarray and real-time reverse transcriptasepolymerase chain reaction analysis. Results: MicroRNA 210 was over expressed in the placentas of preeclamptic pregnancies compared with normal placentas. In mild preeclampsia group the mean micro RNA-210 activity was 1.68±0.25, in severe pre-eclampsia group the mean microRNA-210 activity was 1.89±0.13 and for the control group the mean microRNA-210 activity was 0.99±015. There was highly statistical significance in microRNA-210 activity of the studied groups since the P value for the mild preeclampsia versus the control was 0.0001. For the severe pre-eclampsia versus the control it was 0.0001 and for the severe pre-eclampsia versus mild pre-eclampsia was 0.0001. Conclusions: The results showed that microRNA 210 was over expressed in pre-eclamptic pregnancies (mild and severe), which suggests its involvement in the pathogenesis of pre-eclampsia. | ||
| Keywords | ||
| MicroRNA; placenta; Pre; eclampsia | ||
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