Use of Finasteride- Oral Contraceptive Pill Combination in the Treatment of Polycystic Ovarian Syndrome Related- Infertility

J.U. Al-Rubaie, Bushra; A Al-zubaidy, Adeeb; J. Al-Mukhtar, Entisar

	Use of Finasteride- Oral Contraceptive Pill Combination in the Treatment of Polycystic Ovarian Syndrome Related- Infertility
Medical Journal of Babylon
Article 1, Volume 9, Issue 3, 2012, Pages 688-695
Authors
Bushra J.U. Al-Rubaie; Adeeb A Al-zubaidy; Entisar J. Al-Mukhtar
Abstract
Abstract Background: Polycystic ovarian syndrome (PCOS) is a common endocrinopathy characterized by oligo-ovulation or anovulation, signs of androgen excess, and multiple small ovarian cysts. PCOS is thought to be one of the leading causes of female subfertility. Aim of the study: Evaluate the activity of finasteride - OCP combination in treatment of PCOS related infertility. Patients and Methods: Thirty nine infertile married women at reproductive age were involved in this study; they all were complaining infertility due to PCOS. The diagnosis of PCOS was established depending on the presence of at least two out of three of Rotterdam criteria. The Patients were treated with finasteride 5 mg daily concomitantly with an oral contraceptive pill (OCP) continuously for 2 months. Results: The present study, found that the percentage of patients responded to the treatment with finasteride-OCP combination was (35.89%). The mean number of mature follicles, endometrial thickness & pregnancy rate per patient were (1.21  0.42), (7.261.1 mm) & (21.42%) respectively, whereas miscarriage rate was (0.0 %). Conclusion: The oral finasteride-OCP combination had a good promising effect in the treatment of PCOS related infertility.
Keywords
Finasteride; Oral contraceptive pill; Polycystic ovary syndrome; infertility

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