- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Study the effect of the oral sugar reducer (Glibenclamide 5mg/kg) on Some haematological parameters and the oxidative stress resulted from diabetes activated by Alloxan in the albino rabbits males | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 13, Issue 1, 2013, Pages 72-78 | ||
| Authors | ||
| Muneef Saab Al-janabi; Youssef Shakouri Yasin Al-Samarray; Kawkab Saleem Al-Kaisy | ||
| Abstract | ||
| Due to the aboard application of Glibenclamide as oral reducer of the sugar concentration in blood ,broad this study was designed to estimate the effect of Glibenclamide drug on some blood measurements and its relationship with antioxidant status in Alloxan – induced diabetic albino rabbits.The recent study designed to Know and observe the effect of the sugar reducer and its activity in oxidation-antioxidants (MDA – GSH) as well as its effect on hematological parameters as (PCV and % Hb and RBCs and WBCs and ESR and Platelets numbers).The results of the recent study showed that the activation of the diabetes by Alloxan induction resulted in significant concentration (p≤ 0.05) in decrease concentration of PCV and % Hb and decrease number in RBCs and Platelets number and decrease concentration of GSH ,whereas the results of the study showed a significant increase in the concentration of the MDA and WBCs and count ESR as compared with the healthy control group , whereas the treatment of the Albino rabbits with the oral reducer only led to an insignificant decrease at concentration of significance(p≤ 0.05) as compared with the healthy control group in WBCs and ESR , but there were significant differences in PCV and % Hb and RBCs and MDA. The treatment of the rabbits infected by diabetes activated with the oral reducer showed a significant increase at the concentration of significance (p≤ 0.05) as compared with the infected control group in PCV and % Hb and Platelets number and concentration of GSH but the treatment resulted in a significant increase in the RBCs and WBCs and ESR as well as the concentration of the MDA. | ||
| Keywords | ||
| Glibenclamide; Alloxan in the albino rabbits males | ||
|
Statistics Article View: 191 PDF Download: 121 |
||