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EFFECT OF Citrullus colocynthin ON CERTAIN SPERM FUNCTIONS AND LIVE BIRTH IN MICE: EXPERIMENTAL MODEL FOR MAMMALS | ||
| Journal of University of Babylon | ||
| Article 1, Volume 12, Issue 3, 2006, Pages 552-556 | ||
| Author | ||
| Saad S. Al-Dujaily | ||
| Abstract | ||
| The goal of this study is to find out the effect of Citrullus colocynthin(CC) on sperm function parameters and live birth in mice as a model for mammals. Balb/C male and female mature mice , were used in three experiments. Experiment No.1, the male mice were randomly divided into five groups each contains 6 animals according to different concentrations of CC(2.4,4.8,7.2 and 9.6mg/kg/day) and control group. Experiment No. 2,twenty four females were divided into four groups (6 females in each group)untreated and treated with 1.2 ,4.8, and 7.2 mg/kg/day of CC. Experiment No.3,Four mature male mice were coupled with eight mature females, both were treated only with 4.8mg/Kg/day, and the number of live births were recorded .All the mice groups were treated with CC orally for eight weeks. There was a significant (P<0.05) decrease in the mean of sperm concentration of mice treated with 7.2mg and 9.6 mg /kg/day of CC compared to control, 2.4mg and 4.8 mg/kg/day of mice groups. Percentage of sperm motility and grade activity of progressive movement of mice treated with 4.8 mg/kg/day was significantly (P<0.05) higher than that of other CC concentrations. A highly significant (P<0.01) reduction was observed in the percentage of morphologically abnormal sperm(MAS) following treatment with 4.8mg of CC compared to other groups . There was a significant (P<0.05) increase in the number of live birth in treated male and female group (9.0+0.4) compared to untreated group(6+0.3). The present study revealed that CC in limited doses can be used for invivo improvement of certain sperm characters and to enhance the fertilization ability of the females. | ||
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