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Preparation of Polyvinylpyrrolidinone With Paracetamol as Drug Polymer | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 11, Issue 1, 2012, Pages 177-185 | ||
| Authors | ||
| Firyal M.A.AL-Salami; Abbas N.M. AL-Sharify; Khudheyer J. K | ||
| Abstract | ||
| Abstract: The prodrug polymer was prepared according to ring opening of polyvinyl pyrrollidinone with nuecleophilic attack of hydroxyl group of paracetamol. The new colorless drug polymer was formed with 92% conversion percentage with intrinsic viscosity was equal to (0.61dl/g). The drug polymer was characterized and identified by1H-NMR, IR and UV. Spectroscopy. Controlled released rates were studied in acidic and basic medium at 30 0C and 40 0C. Rate of hydrolysis of paracetamolate ester acts as base > acid, and the rate of release, depends on temperature and pH values. The results show higher hydrolysis at higher temperature as well as higher pH value. | ||
| Keywords | ||
| KEYWORDS; paracetamol; Drug Polymer | ||
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