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Possible Role of Interleukin-6 in Rheumatoid Arthritis | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 49, Issue 2, 2007, Pages 249-252 | ||
| Authors | ||
| Batool A. Al-Haidary; | ||
| Abstract | ||
| Summary: Background: Rheumatoid Arthritis (RA) is an autoimmune disease. Many etiological agents are proposed to play a role in its pathogenecity. One of these factors is cytokines such as Interleukin¬6. Material & Methods: ELISA method has been used for IL-6 estimation in 75 RA patients in comparison with 61 SLE as patient controls and 39 apparently healthy controls. Results: This study showed that there was an elevation of IL-6 in the sera of RA patients with high significant differences between RA patients and controls (P< 0.001). Moreover a good correlation between IL-6 level & RF titer were observed. However, for most patients with high IL-6 were shown to be HLA-DR4. Conclusions: Interleukin-6 play a crucial role in the disease which may be participate in the severity of RA & subsequently its treatment. Key words: RA, IL-6, RF, HLA-DR4, ELISA, Microlymphocytotoxicity | ||
| Keywords | ||
| HLA; ELISA; Microlymphocytotoxicity | ||
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