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HLA-DR and DQ Antigens in Iraqi Patients with Behget's Disease | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 47, Issue 2, 2005, Pages 132-135 | ||
| Authors | ||
| Ph.D. Dr. Raad AL-Muslih; Ph.D. Dr. Khalida M. AL-Mousawy; Ph.D. Dr. Mokaram M.AL- Waiz; ; Ph.D. Dr. Amera Jabir Omar; Dr. Ikbal Kh. AL-Joofy; raad AL-Muslih; khalida Al- Mousawy; mokaram M.AL-Waiz; amera Jaber omer | ||
| Abstract | ||
| Summary: Background: Behqet's disease (BD) is a multisystemic in inflammatoty disorder, disease onset is believed to be triggered by many factors with a particular genetic background. The aim of this study is to investigate the possible correlation between HLA-DR & DQ antigens and onset of this mysterious disease. Method: By using microlymphocytoxicity test, the frequencies of 18 HLA-DR & DQ antigens were calculated in 65 patient with BD compared with 32 patients control with recurrent oral ulcers (ROU) & 115 healthy control. Results: Significant increased trend of HLA-DR52, DR53 and DQ3 antigens (P<0.001), and significant reduced frequencies of DQ4 antigen (P<0.01) in patient with BD as compared to H.C. group, on the other hand significant decreased DR1 antigen in patient with BD (P<0.005) as compared with patients with ROU. Conclusion: Higher frequency of DR52, DR53 & DQ3, these alleles could in one way or another play a crucial role in susceptibility to BD. Whereas DR1 DQ4 phenotypes decrease the risk to develop, this disease. Key words: Behget's disease, HLA- typing HLA-DR and DQ. | ||
| Keywords | ||
| Behget; HLA; typing HLA; DR and DQ | ||
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