Evaluation of some individual antioxidants in seminal plasma of fertile & infertile men.

Biochemist,; J. Ena, Enam; Hathama Razooki Hasan, Dr.

	Evaluation of some individual antioxidants in seminal plasma of fertile & infertile men.
Journal of the Faculty of Medicine
Article 1, Volume 47, Issue 2, 2005, Pages 190-194
Authors
; Enam J. Ena; Dr. Hathama Razooki Hasan
Abstract
(2000) Summary: (2001) Background: infertility is defined as the inability of a couple to conceive after one year of a regular unprotected intercourse with the same partner. Many factors seem to play a role in male infertility. (2002) Aim: to evaluate the role of some seminal plasma biochemical components in male infertility. (2003) Methods: seminal plasma of 100 infertile men & 25 fertile men were chosen as a subject of this study. (2004) Different biochemical parameters that are related to oxidative stress were measured. These included Glutathione Peroxidase (GSHPX),superoxide dismutase (SOD),cerulopasmin (CP) scavenging activity, albumin & total sulfhydral (T-SH) & its individual parts (protein & non protein binding sulfhydral (PB-SH & NP-SH)). (2005) Results:- a significant decrease in GSHPX activity (P<0.05) , T-SH level (P<0.05), BP- SH (P<0.05) & SOD scavenging activity (P<0.01) was observed in infertile men in comparsion to that in the control group. While no significant differences were obsei-ved in albumin & CP scavenging activity between the two studies groups. (2006) Conclusion:- the result of this study indicate the presence of imbalance between pro/antioxidant, which in turn lead to increase in the production of reactive oxygen species in seminal plasma & ultimately cause defect in sperm

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