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The Effect of Ring Size on the Biological Activity of Nitrogen Containing Compounds | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 12, Issue 2, 2012, Pages 75-81 | ||
| Authors | ||
| ; | ||
| Abstract | ||
| Abstract: The biological activity of N-containing ring compounds was studied as a function of the distribution coefficient of these compounds in 1-octanol/water system. The reaction used to monitor activity is the detritiation of 3[H]- acetophenone in dimethylsulfoxide affected by the nitrogen bases understudy at 25.0oC A strong correlation was found between the rate of detretiation of labeled acetophenone and the basicity of N-containing ring cyclic compounds. The correlation coefficient and regression constant were 1.0321 and R2= 0.9415 respectively. This finding shows that similar factors were involved in both cases. Whenever these bases are part of the structure of a drug e.g., they may cause | ||
| Keywords | ||
| Key Words; Partition Coefficient; TLC; DMSO | ||
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