IMMUNOLOGICAL AND INFLAMMATORY RESPONSES OF KILLED AND LIVE NEWCASTLE DISEASE VACCINES IN PIGEONS

S. Ag, Adil; Gar,

	IMMUNOLOGICAL AND INFLAMMATORY RESPONSES OF KILLED AND LIVE NEWCASTLE DISEASE VACCINES IN PIGEONS
AL-TAQANI
Article 1, Volume 25, Issue 4, 2012, Pages 0-0
Authors
Adil S. Ag;
Abstract
This trail was suggested to determine the correlation between the inflammatory and immune responses after the vaccination of domesticated pigeon with killed and live Newcastle disease (ND) vaccines, separately or in combination. For this purpose the evaluation of immune response based on Haemagglutination Inhibition antibody titer (HI-titer), while inflammatory response based on C-Reactive Protein (CRP) level because it’s available commercially. A total of sixty domesticated pigeons were used in the experiment, then those pigeons were divided into four groups, 15 pigeon in each group, each group was propagated separately and had been given water and feed ad libitum. The first group (G1) was vaccinated with ND killed vaccine subcutaneously, the second one (G2) was vaccinated with ND live vaccine orally, while the third group (G3) was got the live vaccine then followed by the killed one within two days, the fourth group (G4) remained as a control group without any vaccine. Blood samples were collected from the pigeons of all groups to estimate the presence of an immunological or inflammatory responses to ND in their own sea within two days intervals for five times to follow up the acute phase proteins CRP and the HI titer. The results showed that the HI titer was elevated slowly but steadily in all vaccinated groups, this elevation was statistically significant at the level p>0.01 in G3, then G2 followed by G1; with no HI titer was detected in G4, while there was abrupt elevation in CRP level at about two days after the vaccination with live and combine vaccines only, no alteration was detected in the group that was vaccinated with killed ND vaccine in comparison with control group. The conclusion is that live ND vaccine induces sufficient level of CRP abruptly after vaccination; HI, as well, had been elevated significantly (p>0.01) in combination with vaccinated group then live vaccine group, and slow elevation in killed vaccine one.

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